The objective is the development, algorithmic design, implementation and validation of robust mathematical optimisation methods for protecting the design of particulate products against uncertainties. Global solution methods will be investigated for optimal robust chromatography as well as synthesis processes, develop-ing methods based on reformulation and decomposition. The obtained results will be validated with the projects. Information on which uncertainties are most relevant and should be reduced, together with recommendations on robust optimum design and quality control, will be returned to the experimental Projects.